Antiquorum Sensing Activity of Methanolic Seed (Nutmeg) Extract of Myristica Fragrans Against a Gram-Positive Bacterium

The increase in multidrug-resistant pathogens has created new anti-pathogenic and anti-virulence compounds. This is because of the behavioural changes bacteria acquire, such as increased antibiotic resistance virulence capacity. social behaviour maintained through a signalling transduction pathway called Quorum sensing. present study aims to evaluate inhibition quorum sensing Bacillus subtilis with Myristica fragrans seed extract. M. nutmeg. Methanolic nutmeg extract was used test anti-quorum activity B. subtilis. Total flavonoid phenolic concentrations were estimated. 10 μg/ml, 30 50 70 μg/ml 90 check against bacterial motilities biofilm formations. Inhibition formation observed under fluorescence microscope, swimming swarming on 0.3 % 0.5 agar plates, respectively. These observations suggest that showed research work helps isolate natural quorum-sensing inhibitors from medicinal plants. can synthesize novel or drugs combat infections by interrupting controlled phenotypes decreasing virulence.